Dr Mark Fraser

Mark has worked in clinical diagnostic mycology at the UKHSA National Mycology Reference Laboratory for 20 years and has undertaken all his professional qualifications in clinical mycology. He is a member of the editorial board for the journal, Medical Mycology (5 year Impact factor 3.91) and he has been an executive committee member of the British Society of Medical Mycology (BSMM).

Mark has taught at each of the universities in Bristol at both undergraduate and Masters level as well as provided teaching for the BSMM led MSc in Medical Mycology at the University of Exeter. He has mentored several BSc/MSc students with successful research projects in the area of clinical mycology. He has also taught at the Pasteur Institute in Paris.

As a clinical scientist, he has been involved in the treatment, management and diagnosis of fungal infections for 13 years. He has presented his research at international, national and local conferences and has published over 40 papers on clinically relevant fungal infections and treatment. His research interests include the taxonomic revision of fungi and the application of this to clinical diagnostics, the development of MALDI-TOF MS as an identification tool for fungi, and the management and treatment of fungal infection.

BSc MSc PhD

Director, Clinical Scientist

HCPC CS17526

Publications

First Author

Fraser, M, Borman, AM, Thorn, R, Lawrance, LM. Resistance to echinocandin antifungal agents in the United Kingdom in clinical isolates of Candida glabrata: Fifteen years of interpretation and assessment. Med Mycol. 2020 Feb 1;58(2):219-226

Fraser M, Borman AM, Johnson EM. Rapid and robust identification of the agents of black-grain mycetoma by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J. Clin. Microbiol. 2017 Aug;55(8):2521-2528

Fraser M, Brown Z, Houldsworth M, Borman AM, Johnson EM. Rapid identification of 6328 isolates of pathogenic yeasts using MALDI-TOF MS and a simplified, rapid extraction procedure that is compatible with the Bruker Biotyper platform and database. Med. Mycol. 2016. Jan;54(1):80-88

Fraser M, Borman AM, Johnson EM. Evaluation of the commercial rapid trehalose test (GLABRATA RTT) for the point of isolation identification of Candida glabrata isolates in primary cultures. Mycopathologia. 2012 Apr;173(4):259-264

Contributing Author

Shelton, JMG., Rhodes, J, Uzzell, CB, Hemmings, S, Brackin, AP, Sewell, TR, Alghamdi, A., Dyer, PS, Fraser, M., Borman, AM, Johnson, EM, Piel, FB, Singer, AC, Fisher, MC. Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols. Science Advances. 2023. Jul 21;9(29)

Abdolrasouli, A. and Fraser, M. Candida auris identification and profiling by MALDI-TOF mass spectrometry. Methods Mol. Biol.,vol. 2517.2022.

Borman AM, Fraser M, Patterson Z, Linton CJ, Palmer M, Johnson EM. Fungal Infections of Implantation: More Than Five Years of Cases of Subcutaneous Fungal Infections Seen at the UK Mycology Reference Laboratory. J Fungi (Basel). 2022 Mar 25;8(4):343.

Borman AM, Fraser M, Patterson Z, McLachlan S, Palmer MD, Mann C, Oliver D, Brown P, Linton CJ, Dzietczyk A, Hedley M, Gough M, Zapata L, North P, Johnson EM. Fungal biomarker testing turn-around-times at the UK National Mycology Reference Laboratory: Setting the record straight. J Infect. 2021 Dec;83(6):e1-e3

Borman AM, Fraser M, Patterson Z, McLachlan S, Palmer MD, Mann C, Oliver D, Brown P, Linton CJ, Dzietczyk A, Hedley M, Gough M, Johnson EM. The considerable impact of the SARS-CoV-2 pandemic and COVID-19 on the UK National Mycology Reference Laboratory activities and workload. Med Mycol. 2021 Nov 3;59(11):1068-1075

Borman AM, Fraser M, Patterson Z, Palmer MD, Johnson EM. In Vitro Antifungal Drug Resistance Profiles of Clinically Relevant Members of the Mucorales (Mucoromycota) Especially with the Newer Triazoles. J Fungi (Basel). 2021 Apr 2;7(4):271

Borman AM, Palmer MD, Fraser M, Patterson Z, Mann C, Oliver D, Linton CJ, Gough M, Brown P, Dzietczyk A, Hedley M, McLachlan S, King J, Johnson EM. COVID-19-Associated Invasive Aspergillosis: Data from the UK National Mycology Reference Laboratory.J Clin. Microbiol. 2020 Dec 17;59(1):e02136-20

Borman AM, Fraser M, Schilling W, Jones G, Pearl R, Linton CJ, Johnson EM. Exophiala campbellii causing a subcutaneous palmar cyst in an otherwise healthy UK resident. Med Mycol Case Rep. 2020 Aug 5;29:43-45

Borman AM, Fraser M, Johnson EM. CHROMagarTM Candida Plus: A novel chromogenic agar that permits the rapid identification of Candida auris. Med Mycol. 2021 Mar 4;59(3):253-258

Borman AM, Hughes JM, Oliver D, Fraser M, Sunderland J, Noel AR, Johnson EM. Lessons from isavuconazole therapeutic drug monitoring at a United Kingdom Reference Center. Med Mycol. 2020 Oct 1;58(7):996-999

Borman AM, Muller J, Walsh-Quantick J, Szekely A, Patterson Z, Palmer MD, Fraser M, Johnson EM. MIC distributions for amphotericin B, fluconazole, itraconazole, voriconazole, flucytosine and anidulafungin and 35 uncommon pathogenic yeast species from the UK determined using the CLSI broth microdilution method. J Antimicrob. Chemother. 2020 May 1;75(5):1194-1205

Borman, AM, Muller, J, Walsh-Quantick, J, Szekely, A, Patterson, Z, Palmer, MD, Fraser, M, Johnson EM. Fluconazole resistance in isolates of uncommon pathogenic yeast species from the UK. Antimicrob Agents Chemother. 2019 Jul 25;63(8):e00211-19

Borman AM, Fraser M, Szekely A, Johnson EM. Rapid and robust identification of clinical isolates of Talaromyces marneffei based on MALDI-TOF mass spectrometry or dimorphism in Galleria mellonella. Med Mycol. 2019 Nov 1;57(8):969-975

Borman AM, Szekely A, Palmer MD, Fraser M, Patterson Z, Johnson EM. The burden of serious fungal disease in the UK- infections with “rare” organisms. J Infect. 2018 Dec;77(6):561-571

Borman AM, Szekely A, Fraser M, Lovegrove S, Johnson EM. A novel dermatophyte relative, Nannizzia perplicata sp. nov., isolated from a case of tinea corporis in the United Kingdom. Med Mycol. 2018 Oct 16

Borman AM, Fraser M, Palmer MD, Szekely A, Houldsworth M, Patterson Z, Johnson EM. MIC distriubutions and evaluation of fungicidal activity for amphotericin B, itraconazole, voriconazole, posaconazole and caspofungin and 20 species of pathogenic filamentous fungi determined using CLSI broth microdilution method. J. Fungi (Basel) 2017 May 31; 3(2)

Borman AM, Fraser M, Szekely A, Larcombe DE, Johnson EM. Rapid identification of clinically relevant members of the genus Exophiala by matrix-assisted laser desorption ionization –time of flight mass spectrometry and description of two novel species, Exophiala campbellii and Exophiala lavatrina. J. Clin. Microbiol. 2017 Apr; 55(4):1162-1176

Fatania N, Fraser M, Savage M, Hart J, Abdolrasouli A. Comparative evaluation of matrix-assisted laser desorption ionisation-time of flight mass spectrometry and conventional phenotypic-based methods for identification of clinically important yeasts in a UK-based medical microbiology laboratory. J. Clin. Pathol. 2015 Dec; 68(12): 1040-1042

Barlow AM, Worledge L, Miller H, Drees KP, Wright P, Foster JT, Sobek C, Borman AM, Fraser M. First confirmation of Pseudogymnoascus destructans in British bats and hibernacula. Vet. Rec. 2015 Jul 18;177(3):73

Borman AM, Fraser M, Linton CJ, Palmer MD, Johnson EM. An improved protocol for the preparation of total genomic DNA from isolates of yeast and mould using Whatman FTA filter papers. Mycopathologia. 2010 Jun; 169(6):445-449

Borman AM, Campbell CK, Fraser M, Johnson EM. Analysis of the dermatophyte species isolated in the british isles between 1980 and 2005 and review of worldwide dermatophyte trends over the last three decades. Med. Mycol. 2007 Mar:45(2):131-141

Dr Mark Fraser

Publications

First Author

Contributing Author

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